AOD-9604 vs 5-Amino-1MQ

AOD-9604 and 5-Amino-1MQ are both studied in fat metabolism research, but they belong to different chemical classes and act on different parts of the metabolic system. AOD-9604 is a modified peptide fragment based on the C-terminal region of human growth hormone, studied for its effects on lipolysis and fat breakdown without the broader growth-promoting activity of the full hormone. 5-Amino-1MQ is a small molecule, not a peptide, that inhibits the enzyme nicotinamide N-methyltransferase (NNMT).

In practical terms, AOD-9604 is used to explore growth hormone fragment signalling in adipose tissue, while 5-Amino-1MQ is used to explore how NNMT activity links cellular energy, NAD+ metabolism and methylation in fat cells. This comparison covers their structure, mechanisms studied, research status and lab handling so researchers can match the compound to the question. PRIME supplies both for laboratory research use only.

AOD-9604: a growth hormone fragment studied in fat metabolism

AOD-9604 is a synthetic peptide derived from the C-terminal region of human growth hormone, the part of the hormone that early research associated with its effects on fat metabolism. The fragment was modified with an additional tyrosine residue at its N-terminus. The aim of this design was to isolate the fat-related activity of growth hormone while leaving out the growth-promoting and IGF-1-related effects of the full molecule.

Preclinical studies have examined AOD-9604 in adipose tissue and in animal models of obesity, looking at lipolysis, the breakdown of stored fat, and at the inhibition of lipogenesis, the formation of new fat. Research has also focused on whether it avoids the effects on blood glucose and insulin sensitivity that are associated with full-length growth hormone. AOD-9604 was investigated in human clinical trials for weight management but was not approved, and it remains a research compound rather than an approved medicine in the US.

Because it is a fragment of a well-studied hormone, AOD-9604 is often used in work that compares fragment activity with the parent hormone, or that examines how growth hormone signalling is divided between metabolic and growth-related pathways.

PRIME supplies AOD-9604 research peptide as a lyophilized powder, with a published lab report for every batch.

5-Amino-1MQ: a small-molecule NNMT inhibitor

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule rather than a peptide. It belongs to a group of methylquinolinium compounds studied as inhibitors of nicotinamide N-methyltransferase, usually shortened to NNMT. 5-Amino-1MQ is a research compound and is not an approved medicine.

NNMT is an enzyme that transfers a methyl group from S-adenosylmethionine to nicotinamide. That reaction sits at a junction between two important cellular systems: the NAD+ salvage pathway, which recycles nicotinamide back into NAD+, and the cell's pool of methyl donors used for many other reactions. NNMT is highly expressed in adipose tissue and liver, and research has reported higher NNMT expression in fat tissue in obesity models.

Preclinical studies with 5-Amino-1MQ have examined how blocking NNMT affects adipocyte metabolism, cellular NAD+ levels and energy expenditure, including work in cultured fat cells and in mice fed high-fat diets. This places it within a broader research interest in NAD+ metabolism and its relationship with metabolic regulation. As a small molecule, it also raises different analytical questions from peptides, such as solubility and stability in the chosen solvent.

Researchers can find 5-Amino-1MQ research compound in the PRIME catalog, with batch documentation published for each lot.

The two compounds suit different mechanistic questions. AOD-9604 fits studies built around growth hormone fragment signalling, lipolysis and lipogenesis in adipose tissue, or comparisons between a hormone fragment and its parent hormone. 5-Amino-1MQ fits studies concerned with enzyme inhibition, NNMT biology, NAD+ salvage and methyl donor balance in fat and liver cells.

A practical difference is chemistry: AOD-9604 is a peptide handled like other lyophilized research peptides, while 5-Amino-1MQ is a small molecule with different solubility and analytical considerations. Studies of metabolic pathways sometimes include both to contrast a hormone-derived signal with an intracellular enzyme target, provided each has clearly defined endpoints. Read the AOD-9604 research guide and the 5-Amino-1MQ research guide for more detail. Because NNMT is closely tied to NAD+ metabolism, the NAD+ research guide is also relevant background.

Confirm the identity and purity of each lot on the PRIME lab results page before use in any experiment.

For laboratory research use only. Not for human consumption.